SCD1 inhibitor-3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SCD1 inhibitor-3是一种安全、有效的具有口服活性的 SCD1 抑制剂。SCD1 inhibitor-3 可用于肥胖症、二型糖尿病、血脂异常等代谢性疾病，以及皮肤病、痤疮、癌症等的研究。

SCD1 inhibitor-3 is a safe, potent and orally active SCD1 inhibitor. SCD1 inhibitor-3 can be used for the research of metabolic diseases such as obesity, type II diabetes and dyslipidemia, as well as skin diseases, acne and cancer.

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SCD1 inhibitor-3 (compound 17a) (5 mg/kg; p.o.; 4 hours) reduces the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.SCD1 inhibitor-3 (2~10 mg/kg; p.o.; 4 hours) makes a dose-responsive reduction of plasma triglycerides desaturation index.Animal Model:Lewis rats Dosage:5 mg/kg Administration:P.o.; 4 hours Result:Reduced the plasma C16:1/C16:0 triglycerides desaturation index by 54 %.Animal Model:Lewis rats Dosage:2~10 mg/kg Administration:P.o.; 4 hours Result:A dose-responsive reduction of plasma triglycerides desaturation index.

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Metabolic Enzyme/Protease

Dehydrogenase

Dehydrogenase

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1282606-48-7

393.37

C19H16FN7O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 125 mg/mL (317.77 mM )

Fc1ccc(Cn2ncn(-c3cc(n[nH]3)C(=O)NCc3cccnc3)c2=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years